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Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments. Statistical methods play a key role in all stages of these trials, including their justification, design, and analysis. This second edition of Introduction to Randomized Controlled Clinical Trials provides a concise presentation of the principles applied in this area. It details the concepts behind randomization and methods for designing and analyzing trials and also includes information on meta-analysis and specialized designs, such as cross-over trials, cluster-randomized designs, and equivalence studies.

This latest edition features new and revised references, examples, exercises, and a new chapter dedicated to binary outcomes and survival analysis. It also presents numerous examples taken from the medical literature, contains exercises at the end of each chapter, and offers solutions in an appendix. The author uses Minitab and R software throughout the text for implementing the methods that are presented.

Comprehensive and accessible, Introduction to Randomized Controlled Clinical Trials is well-suited for those familiar with elementary statistical ideas and methods who want to further their knowledge of the subject.

• Sales Rank: #2840294 in Books
• Brand: Brand: Chapman and Hall/CRC
• Published on: 2006-06-26
• Released on: 2006-06-26
• Original language: English
• Number of items: 1
• Dimensions: 9.13" h x .69" w x 6.13" l, .96 pounds
• Binding: Paperback
• 302 pages

Features

• Used Book in Good Condition

Review

"This remarkably well written book is both concise and thorough in covering the material that it chooses to present. Both statistical concepts and medical examples are explained in clear prose. This is the sort of book that I wish I had had when I first learned about clinical trials. . . . I particularly like Matthews' thoughtful philosophy, which carefully balances the many statistical and medical concerns in the design and analysis of clinical trials. . . . The exercises at the end of each chapter are quite helpful for testing the reader's understanding, and thorough solutions are given in the back of the book. . . . In a sea of overpriced textbooks, it is well worth the low price . . . this book will provide readers with a broad statistical foundation and hopefully whet their interest to learn m ore about clinical trials." -- JASA

About the Author
J. N. S. Matthews, University of Newcastle upon Tyne.

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1 of 2 people found the following review helpful.
Excellent tutorial for those in the field 0-5 years
By Peter Fratarcangelo
Being in this field for over 30 years I believe this should be required reading for all beginning clinical researchers. I have made this mandatory for most members of my staff

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• Sales Rank: #34123 in Books
• Published on: 2014-08-01
• Original language: English
• Number of items: 1
• Dimensions: 7.76" h x .71" w x 5.04" l, .75 pounds
• Binding: Paperback
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About the Author
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55 of 61 people found the following review helpful.
shabby rehash of 2011 version, also out of date already since 2012
By Michael montyman
Many things have changed in Myanmar since so called "Democracy" and since the 2010 elections many places have been opened up to travellers and tourists previously inaccessible before 2012 (unless with expensive govt guide driver and permits etc,) as the country suddenly filled with tourists who previously would not go because of UN sanctions etc , However the NEW 2014 lonely planet guide is just a rehash of the poorly updated 2011 version and a shameful discredit to its author Simon Richmonds reputation . Burma /Myanmar is now become open to backpackers ie overland entry and exit via Kawthung and Maesot . Also overland exit via chin district to India previously unattainable by local bus. Also Mrauk is now accessible by local bus via Ann denied previously. All these points have been igbnored and overlooked in this allegedly updated version and backpackers are still recommended in the guide to follow old prior to democracy routes ie flying and long boat journeys. The book glosses over the plight and genocide of the Rohyngha and is at best just a rehash of the very poor 2011 version. Lonelyplanet and the author Simon Richmond should be ashamed of their lack of principles and efforts in areas where the backpacker will be dissappointed if he/she takes their advice on areas they suggest ie ‘still you can only fly’, whereas those of us who love Myanmar and its people grab these opportunities to head into previously uncharted territory whilst this guide book and its lack of research by the author shows disresepct for those backpackers who are its target, although I personally think its aimed at upmarket accommodation for the "Flashpacker" (see kalow) and yet still sends the naive and trusting backpacker into places noted for their cheating tourists, like Golden Lilly in Kalow etc It lacks research and also lacks important changes in travel within Myanmar as with Mrauk U chin state and Myiktyna etc etc although with hindsight it took 7 years for them to acknowledge Sein Sein in Bhamo as best restaurant, something Stefan loose guide book on Myanmar acknowledged years before and I personally found by accident . Sorry but out of date and disrespectful to those who want a valuable updated guide to this beautiful country. Suggest Lonely planet do a recall and properly update the important changes before the release of the paper back version this month until then use other sources or second hand older version

11 of 11 people found the following review helpful.
Lacking in breadth and depth, but Ok for the casual/first time visitor.
By Giles Peach
While I didn't expect it to have the same breadth of regions/sights as say, Thailand. I was also disappointed with the depth of those areas that are covered.
I'm a frequent traveller to Myanmar and have found both this and the 2 previous editions only semi-useful. This most recent edition definitely feels like it was thrown together just so they could say that they had made an update. Other than a few newer hotels in major destinations, there wasn't that much else put in it seems.
Having said that, if your're just going to the main tourist areas such as Bagan, Inle, Yangon, etc, this will provide you with plenty of things to see and places to stay. If you're really wanting to scratch beneath the surface and get off the beaten track, you're much better off speaking with the undeniably friendly and helpful locals.

6 of 6 people found the following review helpful.
The Best Available...Though Far from Great
By Yoby
Certainly more useful than any other book out there, but Lonely Planet continues to disappoint. Chapters are arranged in illogical order, map legends appear on the pages after the map and someone needs to seriously vet the "highlighted" hotels and restaurants. I found many superior lodgings and eateries with better prices just by walking the streets for a few minutes. I long for the days when Rough Guides regularly published guides in book format, but until they return, Lonely Planet is your best bet. Indispensable if you are travelling independently to Myanmar.

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Will Becoming a Millionaire Really Set You Free? If we, as a nation, declare freedom to be our number one priority, then why do so many of us, at a gut-level, feel less freedom than ever? Americans work harder than ever before to pursue freedom, based on the delusion that more money and success will lead to a better life. The typical American trades the vast majority of their time and energy for the hope that, someday, they will be free. Meanwhile, their intense pursuit of financial success is the very thing robbing them of freedom. So, Where Do We Find Freedom? What Should We Pursue? In Lifeonaire, Steve Cook and Shaun McCloskey challenge you to consider what it is that you really desire. Through this story, they show how Americans often blindly pursue financial wealth thinking that it will reward them with what they want. But, what we really want is life. Our heart's desire is to become more than just a "success" by the world's standards- more than a millionaire. What we really desire is to become a Lifeonaire.

• Sales Rank: #491044 in Books
• Published on: 2014-12-09
• Original language: English
• Dimensions: 8.50" h x .67" w x 5.50" l,
• Binding: Paperback
• 296 pages

Most helpful customer reviews

19 of 21 people found the following review helpful.
One of the best books I have ever read!
By Ugly Scott
When I ordered this book I had not yet heard anything about it. I originally saw it on Facebook. I thought it was a real estate book. I was initially disappointed when i Opened it to find it was a fiction book. I read a lot of business books but never read fiction. I started to read it at about 9:30 pm and stayed up until about 3:30 am to finish it. It was that good. It has really made an impact on my thinking and I am still thinking about this book daily and making the necessary changes. I was definitely pleasantly surprised as I had no expectations going into it. I highly recommend the book!

15 of 18 people found the following review helpful.
Good thought, not very well executed
By John Drew
The point of the book is excellent, living your live a different way then that of the world. I agree 100% with all of the content and maybe some people who have not heard the message need this book to get started.

My problem was this book read more like a cheesy teen devotional then an actual fiction book.

Also, while the idea is good, I think that most people could get more detail and action steps from a book like Dave Ramsey's Total Money Makeover. They are bother similar in content, but Dave's book actually shows you how to take action. Lifeonaire does not give you a good plan on how to get started.

So if you are deep in debt and want a $500,000 boat, you probably shouldn't buy it. In a way, parts of this book is like Suze Orman's "Can I Afford It" where people call in and ask if they can afford ridiculous things even though they're broke.

It also felt like they were self-promoting their seminars which felt a little Guru-ish to me, which I am not a big fan of.

3 of 3 people found the following review helpful.
Real page turner
By Yurintzi Acevedo
This book is truly an inspiration. It has changed my view on life and what my vision entails in living in the NOW while planning for the future. All this while focusing on what's important for me and my family.

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• Published on: 1600
• Binding: Paperback

Most helpful customer reviews

5 of 5 people found the following review helpful.
Ok
By Robert Miller
Ok book, didn't really go into too much detail, very basic. definitely some good info though. I would probably recommend to a friend.

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